Product Name: Cyproterone acetate
Molecular Formula: C24H29ClO4
Molecular Weight: 416.94
Melting Point: 200-201° C
Boiling Point: 525.9oC at 760 mmHg
Flash Point: 177.6° C
Appearance: Crystalline Solid
Standard: Enterprise standard
Usage: The free alcohol is an anti-androgen; The acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne.
Cyproterone acetate (INN, USAN, BAN, JAN), sometimes abbreviated asnCPA, and sold under brand names such as Androcur and Cyprostat, isna synthetic steroidal with additional progestogennand antigonadotropic.
The main therapeutic indications ofncyproterone acetate are prostate cancer, benign prostaticnhyperplasia, priapism, hypersexuality (e.g., as a form of chemicalncastration), and other conditions in which androgen actionnmaintains the disease process.
CPA has been in use as an antiandrogen since 1964, and was the first antiandrogen introduced for clinical use.It is widely used throughout Europe, and is also used in Canada, Mexico, and other countries. It is not FDA-approved for use in the United States.
due to concerns about hepatotoxicity;medroxyprogesterone acetate has been used in this country instead.CPA has been approved for the treatment of prostate cancer, precocious puberty, androgen-related dermatological conditions (such as acne, seborrhea, hirsutism, and androgenic alopecia), and to reduce sex drive in sex offenders.
Combination formulations of CPA with ethinyl estradiol (a formulation sometimes referred to as co-cyprindiol) have been available as contraceptives since 1997.Other uses of CPA include the treatment of benign prostatic hyperplasia, priapism, hypersexuality, paraphilias, hot flashes, and hyperandrogenism in women. In addition, with the exception of the United States (where CPA is not available and spironolactone is generally employed instead), CPA is widely used as a component of hormone replacement therapy.
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